Understand what the science actually says.
Ratings, dosages, and safety in one place.
5-Amino-1-Methylquinolinium (5-Amino-1MQ)
Experimental NNMT inhibitor (IC50 ~1 µM) with preclinical evidence for fat reduction and metabolic improvement in mouse models; no completed human RCTs.
Acetyl-L-Carnitine (ALCAR)
Acetylated form of L-carnitine that crosses the blood-brain barrier; supports mitochondrial function, acetylcholine synthesis, and cognitive performance.
Alpha-GPC (L-Alpha-Glycerylphosphorylcholine)
Alpha-GPC is a highly bioavailable choline compound that crosses the blood-brain barrier, promotes acetylcholine synthesis, and supports cognitive function and muscular performance.
Alpha-Lipoic Acid
Endogenous antioxidant with mitochondrial function; well-documented efficacy in diabetic neuropathy, evidence for metabolic and neuroprotective effects.
Apigenin
Natural flavonoid from chamomile and parsley with anxiolytic, sleep-promoting, anti-inflammatory, and potential longevity effects via CD38 inhibition.
Argireline (topical) / Acetyl Hexapeptide-8
Synthetic hexapeptide (Acetyl Hexapeptide-8) for topical anti-aging applications; reduces expression lines through partial inhibition of the SNARE complex.
Ashwagandha (KSM-66)
Ayurvedic adaptogen (full-spectrum root extract, ≥5% withanolides) with clinical evidence for stress reduction, sleep, cognition, and testosterone.
Astaxanthin
Natural carotenoid from microalgae with potent antioxidant and anti-inflammatory activity; used for skin protection, eye health, and sports performance.
Bacopa Monnieri
Ayurvedic memory herb with well-documented effects on memory, attention, and anxiety reduction; acts via bacoside-mediated cholinergic and antioxidant mechanisms.
BCAA / EAA (Branched-Chain Amino Acids / Essential Amino Acids)
BCAAs (leucine, isoleucine, valine) and EAAs (all 9 essential amino acids) support muscle protein synthesis, recovery, and muscle preservation, particularly when protein intake is insufficient.
Berberine
Plant-derived alkaloid with documented blood glucose- and cholesterol-lowering effects via AMPK activation; EFSA safety assessment 2026 still pending.
Beta-Alanine
Non-essential amino acid that increases muscle carnosine levels and improves performance during high-intensity efforts of 1–4 minutes.
Betaine Hydrochloride
Betaine HCl increases gastric acid levels, supports protein digestion and nutrient absorption in hypochlorhydria.
Fenugreek
Herbal dietary supplement derived from fenugreek seeds with effects on blood glucose, testosterone, and lactation performance; evidence is moderate to contested.
Boron
Boron is a trace element that may support bone health, hormonal balance, and cognitive function; evidence is limited but growing.
BPC-157 (Body Protection Compound 157)
Synthetic 15-amino acid peptide derived from gastric juice protein that promotes tissue healing, angiogenesis, and organ protection in animal models. Clinical evidence in humans remains very limited.
Calcium D-Glucarate
Calcium salt of D-glucaric acid; inhibits beta-glucuronidase and is purported to support glucuronidation. Evidence from animal and in vitro studies; robust human RCTs are lacking.
Cerebrolysin
Cerebrolysin is an injectable neuropeptide mixture derived from porcine brain tissue with neurotrophic properties, used clinically in stroke, dementia, and TBI.
Chaga Mushroom
Parasitic fungus (Inonotus obliquus) with antioxidant, immunomodulatory, and anti-inflammatory properties; evidence to date primarily from animal and in vitro studies.
Citicoline (CDP-Choline)
Citicoline (CDP-choline) is a naturally occurring nucleotide intermediate that promotes phosphatidylcholine synthesis, modulates neurotransmitters, and exhibits neuroprotective effects.
CJC-1295 with Drug Affinity Complex
CJC-1295 DAC is a long-acting GHRH analogue with albumin binding that increases GH and IGF-1 levels in a dose-dependent manner for several days.
CJC-1295 No-DAC
Short-acting synthetic GHRH analogue (half-life ~30 min) that stimulates pulsatile growth hormone secretion; not FDA-approved.
Coenzyme Q10 / Ubiquinol
Endogenous coenzyme with central role in mitochondrial ATP production and as a fat-soluble antioxidant; supplementation particularly relevant with statin use, heart failure, and age-related dec...
Cordyceps
Adaptogenic medicinal mushroom with cordycepin and adenosine as primary active compounds; used for energy, athletic performance, and immunomodulation.
Curcumin (liposomal)
Liposomal curcumin is a highly bioavailable form of the turmeric active compound, encapsulated in phospholipid vesicles, with anti-inflammatory and antioxidant properties.
Delta Sleep-Inducing Peptide (DSIP)
Endogenous nonapeptide that modulates deep (delta-wave) sleep, the HPA axis and the endogenous opioid system; explored experimentally for insomnia and withdrawal syndromes.
DHEA (Dehydroepiandrosterone) – Off-Label
DHEA is an adrenal steroid hormone and prohormone for androgens/estrogens; clinically relevant in adrenal insufficiency and menopausal atrophy.
Dihexa
Experimental hexapeptide derived from Angiotensin IV that activates the HGF/c-Met signaling pathway and improved cognitive deficits in animal studies. No human RCTs available.
3,3'-Diindolylmethane (DIM)
DIM is a phytochemical from cruciferous vegetables that favorably influences estrogen metabolism and is being investigated in hormone-dependent conditions, acne, and potential cancer prevention.
Iron Bisglycinate
Chelated iron form with high bioavailability and good gastrointestinal tolerability for the prevention and treatment of iron deficiency.
Enclomiphene
Enclomiphene is the trans-isomer of clomiphene, a SERM that increases LH, FSH, and endogenous testosterone in men with secondary hypogonadism without suppressing fertility.
Epitalon (Epithalon)
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland; investigated in animal models and in vitro studies for telomerase activation, lifespan extension, and tumor suppression.
Fisetin
Fisetin is a natural flavonoid with senolytic, antioxidant, and neuroprotective properties; clinical human studies remain limited.
Folate (Methylfolate / 5-MTHF)
Biologically active folate form requiring no MTHFR conversion; supports methylation, homocysteine reduction, pregnancy health, and cognitive function.
GHK-Cu (Copper Tripeptide-1)
GHK-Cu is a naturally occurring copper tripeptide with well-documented effects on collagen synthesis, wound healing, and skin regeneration; used primarily as a topical cosmetic.
GHRP-2
Synthetic hexapeptide that stimulates growth hormone release via GHS-R1a receptors; approved in Japan as a diagnostic agent, otherwise a research chemical worldwide.
GHRP-6
Synthetic hexapeptide that triggers growth hormone pulses via activation of the ghrelin receptor (GHS-R1a); experimental, not approved.
Panax Ginseng
Adaptogenic root with evidence for energy, cognitive performance, blood glucose control, and erectile function; effect magnitude moderate.
Glycine
Smallest proteinogenic amino acid with sleep-promoting, anti-inflammatory, and collagen-supporting effects; well-supported by multiple human RCTs.
Gonadorelin
Synthetic GnRH analogue that releases LH and FSH from the pituitary; used in hypogonadism, fertility disorders, and as a diagnostic agent.
Holy Basil (Tulsi)
Adaptogenic Ayurvedic herb with stress-reducing, anti-inflammatory, and immunomodulatory effects; moderate clinical evidence from several small RCTs.
Hexarelin
Hexarelin is a synthetic hexapeptide GHS that stimulates growth hormone release via GHS-R1a and CD36 and exhibits cardioprotective effects. No FDA/EMA approval.
Human Chorionic Gonadotropin (HCG)
Prescription peptide hormone with LH-like activity; medically used for female infertility, hypogonadism, and cryptorchidism.
Human Growth Hormone (HGH, Somatropin)
Prescription recombinant growth hormone for treatment of growth hormone deficiency; significant safety risks outside approved indications.
Humanin
Humanin is a mitochondrially encoded 24-amino acid peptide with neuroprotective, anti-apoptotic, and metabolic properties; exclusively at research stage.
Inositol (Myo / D-Chiro)
Inositol (Myo and D-Chiro) is a vitamin-like compound with well-documented effects in PCOS, insulin resistance, anxiety disorders, and fertility.
Ipamorelin
Synthetic pentapeptide that selectively releases growth hormone from the pituitary without appreciably affecting cortisol or prolactin.
Iodine
Essential trace element for thyroid hormone synthesis; important for metabolism, growth, cognitive development, and pregnancy; frequently inadequate intake in Germany.
Potassium
Essential mineral for blood pressure regulation, nerve and muscle function; well-documented blood pressure-lowering effect at elevated baseline values.
Calcium
Essential mineral for bone, muscle, and nerve function; efficacy of supplements for fracture prevention is debated, cardiovascular risk remains controversial.
Kisspeptin-10
Kisspeptin-10 is an endogenous neuropeptide (10 amino acids) that activates the HPG axis via GnRH and is being investigated in reproductive medicine and sexual medicine.
Collagen Peptides
Hydrolyzed collagen for skin hydration, joint health, bone density, and muscle recovery; high bioavailability due to enzymatic pre-cleavage.
KPV Tripeptide (Lys-Pro-Val)
KPV is a synthetic tripeptide (Lys-Pro-Val) derived from the C-terminus of α-MSH with anti-inflammatory properties in preclinical models – no human data available.
Creatine Monohydrate
Creatine monohydrate is the best-evidenced supplement for strength, muscle mass, and high-intensity performance; increasingly relevant for cognitive health as well.
Krill Oil
Omega-3-rich marine oil from Antarctic krill with EPA/DHA (as phospholipids) and astaxanthin; beneficial effects on blood lipids and inflammatory markers established.
Copper
Essential trace element for enzyme functions, collagen synthesis, iron metabolism, and immune function; deficiency can lead to anemia and neuropathy.
L-Carnitine
L-Carnitine transports long-chain fatty acids into mitochondria for energy production. Evidence for weight loss is weak; stronger data exist for heart failure and male fertility [s1, s2, ...
L-Citrulline
Non-essential amino acid converted in the body to L-arginine and nitric oxide; well-evidenced for muscle pump, endurance performance, and moderate blood pressure reduction.
L-Glutamine
Conditionally essential amino acid for intestinal barrier function, immune function, and muscle recovery; demand increases under intense physical stress or illness.
L-Theanine
Non-proteinogenic amino acid from green tea with demonstrated effects on relaxation, alpha-wave activity, and – in combination with caffeine – cognitive performance.
L-Tyrosine
L-Tyrosine is a non-essential amino acid and precursor of the catecholamines dopamine, norepinephrine, and epinephrine; evidence supports attenuation of stress-induced cognitive deficits.
Larazotide Acetate
Synthetic octapeptide acting as a zonulin antagonist that stabilizes intestinal barrier function; investigated clinically primarily in celiac disease, not yet approved.
Lecithin
Lipid mixture of phospholipids (primarily phosphatidylcholine) serving as a choline source, emulsifier, and potential hepatoprotective agent; evidence for cognitive effects in humans is limited.
Liposomal Glutathione
Glutathione in liposomal encapsulation with improved oral bioavailability; used as an antioxidant, for detoxification support, and immunomodulation.
LL-37 (Human Cathelicidin Antimicrobial Peptide)
Endogenous antimicrobial peptide (37 amino acids) from the cathelicidin family; modulates immune defense, promotes wound healing, and exhibits antiviral activity.
Lion's Mane
Medicinal edible mushroom with neuroprotective properties; promotes NGF synthesis and is investigated for cognitive function, mood, and neuroregeneration.
Maca (Peruvian Ginseng)
Traditional Andean root (Lepidium meyenii) with limited clinical evidence for libido and fertility support; hormonal effects not established.
Magnesium Citrate
Well-bioavailable organic magnesium form with mild laxative effect; used for mineral supplementation, muscle cramps, and constipation.
Magnesium Glycinate
Well-bioavailable, chelated magnesium form supporting sleep quality, muscle relaxation, and stress regulation.
Magnesium L-Threonate
Magnesium L-threonate is a magnesium compound designed to cross the blood-brain barrier, potentially supporting cognitive function, memory, and sleep quality.
Magnesium Malate
Magnesium malate combines magnesium with malic acid (malate) and is used for energy metabolism, muscle recovery, and fibromyalgia symptoms.
Matrixyl (topical)
Matrixyl (Palmitoyl Pentapeptide-4) is a biomimetic signaling peptide used in cosmetics that stimulates fibroblasts to synthesize collagen and reduces wrinkles.
MCT Oil (Medium Chain Triglycerides)
MCT oil provides rapidly available energy from medium-chain fatty acids, supports ketosis, and is used in ketogenic diets, weight management, and for cognitive support [...]
Melanotan II
Synthetic melanocortin analogue for skin tanning and libido enhancement; not approved, significant safety concerns and unclear long-term risk profile.
Melatonin
Endogenous pineal sleep hormone regulating circadian rhythm; effective for sleep onset difficulties, jet lag, and shift work; available without prescription up to 1 mg in Germany.
Metformin (Off-Label Use)
Prescription antidiabetic drug investigated off-label for longevity, weight reduction, and age-related disease prevention.
Methylene Blue (pharmaceutical grade)
Pharmaceutical redox agent with FDA approval for methemoglobinemia; investigated off-label as a nootropic and neuroprotective agent.
Mitoquinol (MitoQ)
Mitoquinol (MitoQ) is a synthetic CoQ10 analogue that selectively accumulates in mitochondria and reduces oxidative stress therein.
MK-677 (Ibutamoren / Ibutamoren Mesylate)
Oral ghrelin receptor agonist that stimulates GH and IGF-1 secretion. Not approved for human use; experimental application in bodybuilding and biohacking community.
Modafinil (Off-Label Use)
Prescription wakefulness-promoting agent used off-label as a cognitive enhancer; evidence for attention and executive functions in healthy individuals is limited.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
MOTS-c is a 16-amino acid peptide encoded by mitochondrial DNA that acts as a metabolic regulator and exercise mimetic.
NAC (N-Acetylcysteine)
NAC is an amino acid precursor of glutathione with antioxidant, mucolytic, and hepatoprotective properties; clinically established in paracetamol overdose and COPD.
Nicotinamide Mononucleotide (NMN)
NMN is an NAD+ precursor molecule that raises NAD+ levels in human studies and shows initial evidence for improvements in insulin sensitivity, muscle strength, and lipid profile.
Nicotinamide Riboside (NR)
Nicotinamide riboside (NR) is a vitamin B3 derivative and NAD⁺ precursor shown to increase NAD⁺ levels; clinical benefit in humans remains largely unclear.
Omega-3 EPA/DHA (Eicosapentaenoic Acid / Docosahexaenoic Acid)
Marine omega-3 fatty acids (EPA and DHA) from fish oil or algal oil with demonstrated effects on triglycerides, inflammatory markers, and cardiovascular endpoints.
P21 Peptide (CNTF-Derived Tetrapeptide)
Synthetic CNTF-derived tetrapeptide that upregulates BDNF, promotes neurogenesis, and improves cognitive performance in animal models. No human data available.
Pentadeca Arginate
Synthetic 15-amino acid peptide (arginate salt form of BPC-157) with preclinical evidence for tissue regeneration, wound healing, and anti-inflammation; no human RCTs available.
Phosphatidylcholine
Phosphatidylcholine is the most abundant membrane phospholipid in the human body, important for liver function, cell membrane integrity, and as a choline source for acetylcholine synthesis.
Phosphatidylserine
Phospholipid component of neuronal membranes; clinical evidence for moderate improvement of memory, concentration, and stress response (HPA axis) in older adults and children with ADHD...
Racetam Family (Piracetam and Analogues)
Synthetic pyrrolidone derivatives for cognitive enhancement; piracetam is the oldest and most extensively studied member of the class.
Prebiotics (Inulin/Fructooligosaccharides)
Inulin and FOS are indigestible dietary fibers with a bifidogenic effect that promote the growth of beneficial gut bacteria and support intestinal health.
Pregnenolone
Pregnenolone is an endogenous neurosteroid and precursor to all steroid hormones; it modulates GABA-A, NMDA, and sigma-1 receptors and is used for cognition, mood, and menopausal symptoms...
Probiotics (Multi-Strains)
Combination of multiple bacterial strains (Lactobacillus, Bifidobacterium, and others) to support gut health, immune function, and potentially mental health.
PT-141 (Bremelanotide)
Cyclic melanocortin peptide for treatment of Hypoactive Sexual Desire Disorder (HSDD) – acts centrally via MC3R/MC4R, not vascularly.
Pterostilbene
Methylated stilbenoid from blueberries with higher bioavailability than resveratrol; initial RCT data on lipid profile and safety available, cognitive effects demonstrated only preclinically to date [s1,...
Pyrroloquinoline Quinone
PQQ is a redox-active micronutrient that supports mitochondrial biogenesis and antioxidant processes; clinical evidence for cognitive benefits is limited.
Quercetin
Plant-derived flavonoid with antioxidant and anti-inflammatory properties; commonly used for allergies, cardiovascular prevention, and as a senolytic.
Rapamycin (Off-Label Use)
Prescription-only mTOR inhibitor; trialed off-label as a longevity agent – robustly extends mouse lifespan, human evidence still limited.
Reishi Mushroom (Ganoderma lucidum)
Reishi (Ganoderma lucidum) is a traditional medicinal mushroom with immunomodulatory, adaptogenic, and antioxidant properties; clinical evidence for many applications remains limited [s1, s...
Resveratrol
Polyphenol from grape skins and Japanese knotweed with antioxidant, cardiovascular, and SIRT1-activating effects; low oral bioavailability (~0.5%).
Retatrutide
Retatrutide is an experimental triple GLP-1/GIP/glucagon receptor agonist by Eli Lilly in Phase 3 clinical development for obesity.
Rhodiola Rosea (Golden Root / Arctic Root)
Plant-derived adaptogen from the root of Rhodiola rosea; reduces stress-related fatigue and supports mental performance according to several RCTs.
Schisandra chinensis
Adaptogenic medicinal herb from TCM with hepatoprotective, antioxidant, and potentially cognitive-supporting properties; evidence to date primarily from animal and in vitro studies for human applications [s1, s...
Selank
Synthetic heptapeptide from Russia with anxiolytic and nootropic effects; modulates GABA, serotonin, and enkephalins; not approved in Germany.
Selenium
Essential trace element with antioxidant activity; important for thyroid function, immune system, and male fertility.
Semaglutide (Ozempic / Wegovy / Rybelsus)
Synthetic GLP-1 analogue for the treatment of type 2 diabetes and obesity; reduces body weight, HbA1c, and cardiovascular risk.
Semax
Synthetic ACTH(4-7)-derived heptapeptide with BDNF/NGF upregulation, approved in Russia for stroke; research chemical outside Russia.
Sermorelin
Synthetic GHRH analogue (amino acids 1–29) that stimulates endogenous growth hormone release from the pituitary gland.
SGLT2 Inhibitors (Gliflozins)
Prescription antidiabetics that inhibit SGLT2 in the renal tubule, demonstrating blood glucose-lowering as well as cardio- and nephroprotective effects.
Spermidine
Naturally occurring polyamine that activates autophagy, slows cellular aging processes, and shows evidence of cognitive and cardiovascular protective effects in studies.
SR-9009 (Stenabolic)
SR-9009 is a synthetic REV-ERBα/β agonist investigated exclusively in animal and cell studies. No human clinical data available.
Taurine
Taurine is a naturally occurring aminosulfonic acid with well-documented effects on cardiovascular health, muscle recovery, and metabolic parameters.
TB-500 (Thymosin Beta-4 Fragment)
Synthetic heptapeptide (Ac-LKKTETQ) derived from the active fragment of endogenous Thymosin Beta-4. Not approved for human use; investigated in animal and early human studies for tissue regenerat...
Tesamorelin
Synthetic GHRH analogue, FDA-approved for reduction of abdominal fat in HIV-associated lipodystrophy; not approved in the EU.
Thymosin Alpha-1
Synthetic 28-amino acid peptide with immunomodulatory activity; approved in over 35 countries for hepatitis and immunodeficiencies, but not in the EU/Germany.
Thymulin
Thymulin is a zinc-containing nonapeptide of the thymus that regulates T-cell differentiation and immunomodulation – supported predominantly by animal and in vitro studies only.
Tirzepatide (Mounjaro / Zepbound)
Tirzepatide is a dual GIP/GLP-1 receptor agonist for the treatment of type 2 diabetes and obesity with very potent effects on blood glucose and body weight.
Tongkat Ali (Eurycoma longifolia)
Herbal extract from the root of Eurycoma longifolia to support testosterone levels, libido, stress hormone profile, and athletic performance.
Tribulus terrestris
Plant-based supplement derived from Tribulus terrestris containing steroidal saponins (protodioscin), traditionally used to enhance libido and sexual function; clinical evidence for testosterone incr...
Urolithin A
Urolithin A is a gut microbiome metabolite derived from ellagitannins that activates mitophagy and improves muscle function and mitochondrial health.
Vasoactive Intestinal Peptide (VIP)
VIP is an endogenous 28-amino acid neuropeptide with potent anti-inflammatory, vasodilatory, and immunomodulatory effects; investigated clinically in early phases for ARDS and PAH [s5, ...
Digestive Enzymes
Enzyme preparations containing amylase, lipase, protease, lactase, and others to support digestion in enzyme insufficiency, flatulence, and food intolerances.
Vitamin A (Retinol)
Fat-soluble vitamin essential for visual function, immune defense, cell differentiation, and skin integrity; hepato- and teratotoxic in overdose.
Vitamin B Complex
Combination of all eight water-soluble B vitamins (B1, B2, B3, B5, B6, B7, B9, B12) to support energy metabolism, nervous system function, and hematopoiesis.
Vitamin B1 (Thiamin) + B2 (Riboflavin)
Water-soluble B vitamins acting as essential coenzymes in energy metabolism, the nervous system, and the antioxidant defense system.
Vitamin B12 (Methylcobalamin)
Bioactive form of vitamin B12; directly utilizable without conversion in the body. Supports nerve function, methylation metabolism, and homocysteine degradation.
Vitamin C (Ascorbic Acid)
Water-soluble essential vitamin with antioxidant activity, roles in collagen synthesis, immune function, and iron absorption; well-established for reducing common cold duration.
Vitamin D3 + K2 (Cholecalciferol + Menaquinone)
Synergistic combination of fat-soluble vitamin D3 (calcium absorption) and K2 (calcium directing into bone, vascular protection) for bone and cardiovascular health.
Vitamin E (Tocotrienols)
Tocotrienols are the lesser-known vitamin E family with an unsaturated side chain; they exhibit stronger antioxidant and potentially lipid-lowering and neuroprotective effects than tocopherols...
Vitamin K2 MK-7 (Menaquinone-7)
Highly bioavailable form of vitamin K2 with long half-life; activates osteocalcin and MGP for bone preservation and inhibition of arterial calcification.
Zinc Bisglycinate
Chelated zinc form with +43% higher bioavailability than zinc gluconate; well tolerated; supports immune function, skin, hair, and wound healing.